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In this project our medicine box is targeted on users who regularly take medicine or vitamin supplements or nurses who take care of the older patients. Our medicine box is programmable that allows nurses or users to specify the pill quantity and day to take pills and the save times for each day. Our smart medicine box contains six separate sub-boxes. [7] Therefore, doctors/nurses or users can set information for six different pills. When the pill quantity and time have been set, the medicine box will remind users or patients to take pills using sound and light. A LCD, placed in controller unit will provide the information about the pills. Compared with the traditional pill box it requires users or nurses to load the box every day or every week. Smart medicine box would significantly release nurses or users’ burden on frequently preloading pills for patients or users. [2] To make it a grand success, internet of things is one of the latest internet technology developed. Various designs have already been proposed and have advantages as well as disadvantages. The project is a review of smart medicine box based on IOT. [5] Doctors/Nurses can send the entire prescription to the smart medicine box using a mobile application. [2] Our system will store data in its local serve to user in more efficient manner.